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Regulation of HSF1-Mediated Heat Shock Response - Ontify

Regulation of HSF1-Mediated Heat Shock Response

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-3371453).

Statements about Regulation of HSF1-Mediated Heat Shock Response

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Instance Of

Biological Pathway

Regulation of Cellular Response to Heat

Part Of

Cellular Response to Heat Stress

Has Part(s)

14 items

Constitutive Phosphorylation by pERK1/2

Constitutive Phosphorylation by GSK3

P-S303,307-HSF1 Binds YWHAE (14-3-3)

MAPKAPK2 Phosphorylates HSF1

RPA1 Binds HSF1

DBC1 Is Phosphorylated by ATM/ART

DBC1 Binds SIRT1

SIRT1 Binds to HSF1

SIRT1 Deacetylates HSF1

HSP40s Activate Intrinsic ATPase Activity of HSP70s in the Cytosol

Hikeshi Binds HSP70s:ATP

NPC Transports Hikeshi:HSP70s:ATP From Cytosol to Nucleoplasm

HSP110s Exchange ATP for ADP on HSP70s:ADP

HSP40s Activate Intrinsic ATPase Activity of HSP70s in the Nucleoplasm

Exact Match

https://identifiers.org/reactome:R-H ...