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Macroautophagy - Ontify
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Macroautophagy
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1632852).
Statements about
Macroautophagy
Instance Of
Biological Pathway
Macroautophagy
Has Part(s)
40 items
P-AMPK:AMP Phosphorylates Raptor in the MTORC1 Complex
MTORC1 Dissociates From ULK Complex
P-AMPK:AMP Binds the ULK Complex
AMPK (Complex) Phosphorylates ULK1 (Complex)
Thr-180 of ULK1 Is Phosphorylated
ULK1 Phosphorylates ATG13 and RB1CC1
Autophagosome Maturation
Selective Autophagy
Exact Match
https://identifiers.org/reactome:R-H ...
Part Of
Autophagy
Active MTORC1 Phosphorylates ULK1
Active MTORC1 Binds the ULK1 Complex
Beclin-1 Complex Phosphorylates PtdIns
ULK1 Is Dephosphorylated
WIPI2 Binds ATG12:ATG5:ATG16L
Beclin-1 Complex Translocates to the ER
ULK1 Phosphorylates AMBRA1:BECN1 Complex
MTMR14, MTMR3 Dephosphorylate PI3P
ULK1 Phosphorylates Beclin-1
ATG12 Binds ATG7 Dimer
ATG16L1 Complex Transfers LC3 From ATG3 to PE
BECN1 Complex, P-AMBRA1 Dissociate From DYNLL1,DYNLL2
LC3 Binds ATG7 Dimer
AMBRA1:DYNLL1,DYNLL2 Binds BECN1 Complex
ATG10 Transfers ATG12 From ATG7 to ATG10
ATG5:ATG12 Binds ATG16L1
LC3 De-Lipidation by ATG4
ATG12:ATG7:CysO572-ATG7 Binds ATG10
LC3 Is Cleaved by ATG4
AMBRA1 Binds DYNLL1,DYNLL2
ATG10 Dissociates From ATG12:ATG5
ATG10 Transfers ATG12 From ATG10 to ATG5
ATG3 Transfers LC3 From ATG7 to ATG3
LC3:ATG7 Dimer Binds ATG3
ATG12 Forms a Thioester Bond with ATG7 Dimer
The Phagophore Extends From the PIP3-Enriched Structure
WIPIs Bind PI3P
ATG10:ATG12 Binds ATG5
ATG10:ATG12:ATG7 Dimer Dissociates
Rheb in the MTORC1 Complex Hydrolyses GTP
ULK Complex Translocates to the ER
ATG7:ATG3:LC3 Dissociates
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