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SCF(Skp2)-Mediated Degradation of P27/P21 - Ontify

SCF(Skp2)-Mediated Degradation of P27/P21

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-187577).

Statements about SCF(Skp2)-Mediated Degradation of P27/P21

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Instance Of

Biological Pathway

Part Of

Cyclin E Associated Events During G1/S Transition

Cyclin A:Cdk2-Associated Events at S Phase Entry

Has Part(s)

Cyclin E/A:Cdk2-Mediated Phosphorylation of P27/P21

Association of Cks1 with SCF(Skp2) Complex

Binding of Phospho-P27/P21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 Complex

Degradation of Ubiquitinated P27/P21 by the 26S Proteasome

Ubiquitination of Phospho-P27/P21

Activated PTK6 Binds CDKN1B

PTK6 Phosphorylates CDKN1B

Exact Match

https://identifiers.org/reactome:R-H ...