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Cyclin D Associated Events in G1 - Ontify

Cyclin D Associated Events in G1

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-69231).

Statements about Cyclin D Associated Events in G1

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Instance Of

Biological Pathway

Part Of

Has Part(s)

16 items

Association of INK4 Family Proteins with CDK4/6

Formation of CDK4/6:CCND Complexes

Cip/Kip CDK Inhibitors Bind CDK4/6:CCND Complexes

Tyrosine Kinases Phosphorylate Cip/Kip Inhibitors Bound to CDK4/6:CCND Complexes

Translocation of CDK4/6:CCND Complexes From the Cytoplasm to the Nucleus

Cyclin D:CDK4/6 Mediated Phosphorylation of P107 (RBL1) and Dissociation of Phosphorylated P107 (P-RBL1) From DP1:E2F4 Complex

Dephosphorylation of P107 (RBL1) by PP2A

Cyclin D:CDK4/6 Phosphorylates RB1 and Prevents RB1 Binding to E2F1/2/3:DP1/2 Complexes

CDK4/6:CCND Complexes Are Activated by T-Loop Phosphorylation of CDK4/6

Cyclin D:Cdk4/6 Mediated Phosphorylation of P130 (RBL2) and Dissociation of Phosphorylated P130 (RBL2) From DP1:E2F4/5 Complex

Dephosphorylation of P130 (RBL2) by PP2A

Phosphorylated P130 (RBL2) Binds SCF(Skp2):Cks1 Complex

Ubiquitination of P130 (RBL2) by SCF (Skp2)

RB1 Binds and Inhibits E2F1/2/3:DP1/2 Complexes

RB1 Translocates to the Nucleus

Drug-Mediated Inhibition of CDK4/CDK6 Activity

Exact Match

https://identifiers.org/reactome:R-H ...