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Cholesterol Biosynthesis - Ontify

Cholesterol Biosynthesis

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-191273).

Statements about Cholesterol Biosynthesis

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Instance Of

Biological Pathway

Cholesterol Biosynthetic Process

Part Of

Metabolism of Steroids

Has Part(s)

31 items

MVD Decarboxylates MVA5PP to IPPP

CYP51A1 Demethylates LNSOL

Exact Match

https://identifiers.org/reactome:R-H ...

Mevalonate-5-Phosphate Is Further Phosphorylated.

FDPS Dimer Transfers IPPP to GPP

ACAT2 Condenses 2 Ac-CoA to Form ACA-CoA

FDPS Dimer Transfers IPPP to DMAPP

Phospholipid Phosphatase 6 Hydrolyses Presqualene Diphosphate to Presqualene Monophosphate

Two FPP Molecules Dimerize to Form Presqualene Diphosphate

4,4-Dimethylcholesta-8(9),24-Dien-3beta-Ol Is Oxidized to 4-Methyl,4-Carboxycholesta-8(9),24-Dien-3beta-Ol

4-Methyl,4-Carboxycholesta-8(9),24-Dien-3beta-Ol Is Decarboxylated and Oxidized to Form 4-Methylcholesta-8(9),24-Dien-3-One

HMGCR Dimer Reduces bHMG-CoA to MVA

4,4-Dimethylcholesta-8(9),14,24-Trien-3beta-Ol Is Reduced to 4,4-Dimethylcholesta-8(9),24-Dien-3beta-Ol [TM7SF2]

HMGCS1 Condenses Ac-CoA and ACA-CoA to Form bHMG-CoA

Mevalonate Is Phosphorylated to Mevalonate-5-Phosphate

Cholesterol Biosynthesis via Desmosterol

4,4-Dimethylcholesta-8(9),14,24-Trien-3beta-Ol Is Reduced to 4,4-Dimethylcholesta-8(9),24-Dien-3beta-Ol [LBR]

4-Methylcholesta-8(9),24-Dien-3beta-Ol Is Oxidized to 4-Carboxycholesta-8(9),24-Dien-3beta-Ol

4-Methylcholesta-8(9),24-Dien-3-One Is Reduced to 4-Methylcholesta-8(9),24-Dien-3beta-Ol

Isopentenyl Pyrophosphate Rearranges to Dimethylallyl Pyrophosphate

GGPS1 Hexamer Transfers IPPP to GPP

ARV1 Transports CHOL From ER Membrane to Plasma Membrane

GGPS1 Hexamer Transfers IPPP to DMAPP

Cholesterol Biosynthesis via Lathosterol

Squalene Is Oxidized to Its Epoxide

Squalene 2,3-Epoxide Cyclizes, Forming Lanosterol

Reduction of Presqualene Diphosphate to Form Squalene

4-Carboxycholesta-8(9),24-Dien-3beta-Ol Is Decarboxylated and Oxidized to Form Cholesta-8(9),24-Dien-3-One (Zymosterone)

HMGCR Dimer Binds Statins

Zymosterone (Cholesta-8(9),24-Dien-3-One) Is Reduced to Zymosterol (Cholesta-8(9),24-Dien-3beta-Ol)

Holo-FDPS Dimer Binds NBPs

DHCR24 Reduces LAN to 24,25-dhLAN