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Azathioprine ADME - Ontify
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Azathioprine ADME
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9748787).
Statements about
Azathioprine ADME
Exact Match
https://identifiers.org/reactome:R-H ...
Instance Of
Biological Pathway
Xenobiotic Metabolic Process
Has Part(s)
18 items
GSH Cleaves AZA to 6MP
NME1:2 Hexamer Phosphorylates 6TdGDP to 6TdGTP
GUK1 Phosphorylates 6TdGMP to 6TdGDP
P-VAV1,2,3 Exchange 6TGTP for GDP on RAC1
NME1:2 Hexamer Phosphorylates 6TGDP to 6TGTP
GST Dimers Cleave AZA to 6MP
NUDT15 Dimer Dephosphorylates 6TdGTP to 6TdGMP
ABCC5 Transports TPMP Substrates From Cytosol to Extracellular Region
XDH Oxidises 6MP to 6TU
GMPS Dimer Transforms 6TXMP to 6TGMP
SLC28A2,3 Cotransport 6MP and Na+ From Extracellular Region to Cytosol
TPMT Transfers Methyl Group to 6TIMP, Forming 6MeTIMP
ABCC4 Transports TPMP Substrates From Cytosol to Extracellular Region
IMPDH Tetramers Dehydrogenate 6TIMP to 6TXMP
SLC29A1,2 Transport 6MP From Extracellular Region to Cytosol
HPRT1 Tetramer Transfers Phosphoribosyl Group to 6MP to Form 6TIMP
TPMT Transfers Methyl Group to 6MP, Forming 6MeMP
GUK1 Phosphorylates 6TGMP to 6TGDP
Part Of
ADME
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