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Defective D-Loop Formation Mediated by PALB2, BRCA2 and RAD51 Due to Loss-of-Function of PALB2 in Binding to BRCA2/RAD51/RAD51C

Instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9704408).

Statements about Defective D-Loop Formation Mediated by PALB2, BRCA2 and RAD51 Due to Loss-of-Function of PALB2 in Binding to BRCA2/RAD51/RAD51C

Exact Match

https://identifiers.org/reactome:R-H ...

Instance Of

Biological Process

Has Part(s)

3' Overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C Complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-T309-RAD51:p-T3387-BRCA2:SEM1:BCDX2 Complex [Nucleoplasm]
Object of Statement Has Role
:
Reactant
Unnamed
: 1
PALB2 Mutants (BRCA2/RAD51/RAD51C Binding) [Nucleoplasm]
Object of Statement Has Role
:
Reactant
Unnamed
: 1
RAD51 Associated Protein 1
Object of Statement Has Role
:
Reactant
Unnamed
: 1

Part Of

Defective HDR Through Homologous Recombination Repair (HRR) Due to PALB2 Loss of BRCA2/RAD51/RAD51C Binding Function
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