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Pyroptosis - Ontify
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Pyroptosis
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5620971).
Statements about
Pyroptosis
Exact Match
https://identifiers.org/reactome:R-H ...
Instance Of
Biological Pathway
Pyroptosis
Has Part(s)
23 items
IRF2 or IRF1 Binds the GSDMD Gene Promoter
GSDMD Expression Mediated by IRF2, IRF1
TP53 or TP63 Binds the GSDME Gene
GSDME Expression Mediated by TP53, TP63
CASP1 Cleaves GSDMD
CASP4, CASP5 Cleave GSDMD
ELANE Cleaves GSDMD
Dimethyl Fumarate Modifies Cys191 in GSDMD
GSDMD (1-275) Binds PIPs
Disulfiram Covalently Modifies Cys191 in GSDMD
GSDMD Oligomerizes Into Arc-, Slit-Shaped Structures
GSDMD Forms Ring‐shaped Oligomers
GSDMD (1-275) Binds Bacterial Cardiolipin
CASP3 Cleaves GSDMD
CASP3 Cleaves GSDME
GZMB Cleaves GSDME
GSDME (1-270) Binds PIPs
GSDME Oligomerizes
GSDMD (1-275) Binds Cardiolipin
GSDME (1-270) Binds Cardiolipin
Release of Cytochrome C From Mitochondria
Interleukin-1 Family Are Secreted
HMGB1 Release From Cells
Part Of
Regulated Necrosis
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