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Replication of the SARS-CoV-2 Genome
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9694686).
Statements about
Replication of the SARS-CoV-2 Genome
Exact Match
https://identifiers.org/reactome:R-H ...
Instance Of
Biological Pathway
Has Part(s)
22 items
Replication Transcription Complex Binds SARS-CoV-2 Genomic RNA
Nsp13 Helicase Melts Secondary Structures in SARS-CoV-2 Genomic RNA Template
Nsp8 Generates RNA Primers
Nsp12 Synthesizes Minus Strand SARS-CoV-2 Genomic RNA Complement
Nsp12 Misincorporates a Nucleotide in Nascent RNA Minus Strand
SARS-CoV-2 gRNA:RTC:RNA Primer Binds RTC Inhibitors
Nsp14 Acts as a 3'-to-5' Exonuclease to Remove Misincorporated Nucleotides From Nascent RNA
RTC Completes Synthesis of the Minus Strand Genomic RNA Complement
SARS-CoV-2 gRNA:RTC:nascent RNA Minus Strand Binds RTC Inhibitors
RTC Binds SARS-CoV-2 Genomic RNA Complement (Minus Strand)
RTC Synthesizes SARS-CoV-2 Plus Strand Genomic RNA
SARS-CoV-2 gRNA Complement (Minus Strand):RTC Binds RTC Inhibitors
Polyadenylation of SARS-CoV-2 Genomic RNA (Plus Strand)
ZCRB1 Binds 5'UTR of SARS-CoV-2 Genomic RNA
Part Of
SARS-CoV-2 Genome Replication and Transcription
Nsp13 Binds DDX5
Nsp14 Acts as a Cap N7 Methyltransferase to Modify SARS-CoV-2 gRNA Complement (Minus Strand)
Nsp14 Acts as a Cap N7 Methyltransferase to Modify SARS-CoV-2 gRNA (Plus Strand)
Nsp16 Acts as a Cap 2'-O-Methyltransferase to Modify SARS-CoV-2 gRNA (Plus Strand)
Nsp16 Binds VHL
Nsp15 Cleaves Viral Poly(U)-RNA
Nsp16 Acts as a Cap 2'-O-Methyltransferase to Modify SARS-CoV-2 gRNA Complement (Minus Strand)
Nsp15 Binds RB1
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