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FLT3 Signaling - Ontify
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FLT3 Signaling
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9607240).
Statements about
FLT3 Signaling
Exact Match
https://identifiers.org/reactome:R-H ...
Instance Of
Biological Pathway
Cytokine-Mediated Signaling Pathway
Has Part(s)
27 items
FLT3LG Dimer Binds FLT3
FLT3LG Dimer:FLT3 Binds FLT3
FLT3LG Dimer:FLT3 Dimer Autophosphorylates
Active FLT3 Dimer Binds GRB2
Active FLT3:GRB2 Binds SOS1
SOS1-Mediated Nucleotide Exchange of RAS Downstream of FLT3
Active FLT3:GRB2 Binds GAB2
GAB2 in Active FLT3:GRB2:GAB2 Is Phosphorylated
Active FLT3:GRB2:p-Y-GAB2 Binds PIK3R1
Active FLT3:GRB2:p-Y-GAB2 Binds PTPN11
Active FLT3 Binds PTPN11
STAT5 Activation
FLT3 Signaling Through SRC Family Kinases
Active FLT3 Binds to GRAP2
Active FLT3 Binds to GRB10
FLT3 Phosphorylates GRB10
Active FLT3:p-Y-GRB10 Binds PIK3R1
Active FLT3:p-Y GRB10:PIK3R1 Binds PIK3CA
Active FLT3:GRB2:p-GAB2:PIK3R1 Binds PIK3CA
AKT Phosphorylates FOXO3 Downstream of FLT3
AKT-Phosphorylated FOXO3 Translocates to Cytosol
FOXO3-Dependent BCL2L11 Gene Expression
FOXO3-Dependent CDKN1B Gene Expression
Active FLT3 Phosphorylates CDKN1B
FLT3 Binds Type I TKI
FLT3 Binds Type II TKI
Negative Regulation of FLT3
Part Of
Cytokine Signaling in Immune System
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