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Alpha-Protein Kinase 1 Signaling Pathway - Ontify
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Alpha-Protein Kinase 1 Signaling Pathway
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9645460).
Statements about
Alpha-Protein Kinase 1 Signaling Pathway
Exact Match
https://identifiers.org/reactome:R-H ...
Instance Of
Biological Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Has Part(s)
10 items
ALPK1 Binds ADP-Heptose
ALPK1:ADP-Heptose Binds TIFA
ALPK1 Phosphorylates TIFA
TIFA Oligomerization
ALPK1:ADP-Heptose:TIFA Oligomer Recruits TRAF6
TRAF6 Oligomerizes Within the ALPK1:ADP-Heptose:TIFA Oligomer Complex
Auto Ubiquitination of TRAF6 Bound to ALPK1:ADP-Heptose:TIFA Oligomer
Activated TRAF6 Synthesizes Unanchored Polyubiquitin Chains upon ALPK1:ADP-Heptose Stimulation
ALPK1:ADP-Heptose:p-T9-TIFA Oligomer:K63pUb-TRAF6 Oligomer Recruits MAP3K7 (TAK1)
Auto Phosphorylation of TAK1 Within the ALPK1:ADP-Heptose:p-T9-TIFA:pUb-TRAF6: Free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 Complex
Part Of
Innate Immune System
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