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FCGR3A-Mediated IL10 Synthesis - Ontify

FCGR3A-Mediated IL10 Synthesis

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9664323).

Statements about FCGR3A-Mediated IL10 Synthesis

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Instance Of

Biological Pathway

Negative Regulation of Inflammatory Response to Antigenic Stimulus

Has Part(s)

20 items

IgG Binds LPG1G2 in the Amastigote Form of Leishmania

IgG Binds the Surface of the Amastigote Form of Leishmania

Opsonized Leishmania Amastigote Binds FCGR3

Src Phosphorylates CD3 Dimers in IgG:Lma Antigens:FCGR3A:CD3 Dimers

SYK Binds IgG:Lma Antigens:FCGR3A:p-CD3 Dimers

Src Phosphorylate SYK in IgG:Leishmania Surface:p-FCGR3A:SYK

Recruitment of PLCgamma to Membrane Due to FCGR3A Effect

Phosphorylation and Activation of PLCG Due to FCGR3A Effect

Release of PLCG From FCGR3A

PLC-Gamma1 Hydrolyses PIP2

IP3 Binds to the IP3 Receptor, Opening the Endoplasmic Reticulum Ca2+ Channel

IP3R:I(1,4,5)P3 Tetramer Transports Ca2+ From ER Lumen to Cytosol

Calcium Binds Calmodulin

Adenylate Cyclase Produces cAMP

CAMP Binds PKA Tetramer

CAMP Induces Dissociation of Inactive PKA Tetramers

PKA Catalytic Subunit Translocates to the Nucleus

PKA Phosphorylates CREB1

CREB1 Binds IL-10 Promoter

IL10 Gene Produces IL10 Protein

Part Of

Anti-Inflammatory Response Favouring Leishmania Parasite Infection