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Purinergic Signaling in Leishmaniasis Infection - Ontify
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Purinergic Signaling in Leishmaniasis Infection
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9660826).
Statements about
Purinergic Signaling in Leishmaniasis Infection
Exact Match
https://identifiers.org/reactome:R-H ...
Instance Of
Biological Pathway
Purinergic Nucleotide Receptor Signaling Pathway
Has Part(s)
23 items
C3a Receptor Binds Anaphylatoxin C3a
ATP Translocates From Cytosol to Extracellular Space (Stimuated by C3AR1:C3a)
ATP Binds P2RX4,7
NTPDase1 Hydrolyzes Nucleoside Triphosphates
NTPDase5 Hydrolyzes Nucleoside Diphosphates
NT5E:Zn2+ Hydrolyses NMN
P2RX4,7 Binds Itself to Form Trimeric Non-Selective Cation Channels
SGT1 Binds HSP90
SGT1:HSP90 Binds Inactive NLRP3
TXNIP Binds Reduced Thioredoxin
ROS Oxidize Thioredoxin
TXNIP Is Released From Oxidized Thioredoxin
Expression of NLRP3 Gene
TXNIP Binds NLRP3
NLRP3 Activation by Small Molecules
NLRP3 Recruits PYCARD (ASC) via a PYD-PYD Interaction
PYCARD Recruits Procaspase-1 via CARD
PSTPIP1 Binds Pyrin
Pyrin Binds ASC
CTSG Cleaves CASP1(1-404)
Caspase-1 Active Tetramer Formation
Interleukin-1 Family Precursors Are Cleaved by Caspase-1
Interleukin-1 Family Are Secreted
Part Of
Cell Recruitment (Pro-Inflammatory Response)
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