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FCGR3A-Mediated Phagocytosis - Ontify

FCGR3A-Mediated Phagocytosis

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9664422).

Statements about FCGR3A-Mediated Phagocytosis

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Exact Match

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Instance Of

Biological Pathway

Fc-Gamma Receptor Signaling Pathway Involved in Phagocytosis

Has Part(s)

27 items

IgG Binds the Surface of the Amastigote Form of Leishmania

IgG Binds LPG1G2 in the Amastigote Form of Leishmania

IgG:Lma Antigens Binds FCGR3A:CD3 Dimers

Src Phosphorylates CD3 Dimers in IgG:Lma Antigens:FCGR3A:CD3 Dimers

SYK Binds IgG:Lma Antigens:FCGR3A:p-CD3 Dimers

Src Phosphorylate SYK in IgG:Leishmania Surface:p-FCGR3A:SYK

PI(3,4,5)P3 Binds VAV1,2,3

VAV1,2,3:PI(3,4,5)P3 Binds P-6Y-SYK

P-6Y-SYK Phosphorylates VAV1,2,3

P-VAV1,2,3 Exchanges GTP for GDP on RAC1:GDP

CRKII:DOCK180:ELMO Binds FCGR3A

DOCK180 Exchanges GTP for GDP on RAC1:GDP

RAC1:GTP and PIP3 Bind WAVE Regulatory Complex (WRC)

P-ERK Phosphorylates WAVEs and ABI

ABL Phosphorylates WAVEs

An Unknown GEF Exchanges GTP for GDP on CDC42:GDP

PtdIns(4,5)P2 Binds WASP, N-WASP

CDC42:GTP Binds PtdIns(4,5)P2:WASP,N-WASP

Activation of WASP and N-WASP by CDC42

WIP Binds WASP,N-WASP, Activating Them

Src Phosphorylate WASP,N-WASP

WASPs or WAVEs Activate the ARP2/3 Complex

(WASPs, WAVE):G-Actin:ARP2/3 Binds F-Actin

Detachment of WASP/WAVE

Branching and Elongation of Mother and Daughter Filaments

Extension of Pseudopodia by Myosin-X in a PI3K Dependent Manner

IgG:Leishmania Surface:FCGR3A Translocates From Plasma Membrane to the Parasitophorous Vacuole

Part Of

Leishmania Phagocytosis