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Signaling by PDGFRA Transmembrane, Juxtamembrane and Kinase Domain Mutants - Ontify

Signaling by PDGFRA Transmembrane, Juxtamembrane and Kinase Domain Mutants

Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9673767).

Statements about Signaling by PDGFRA Transmembrane, Juxtamembrane and Kinase Domain Mutants

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Exact Match

https://identifiers.org/reactome:R-H ...

Instance Of

Biological Pathway

Has Part(s)

SOS-Mediated Nucleotide Exchange of RAS Downstream of Mutant PDGFR Receptors

STAT Binds to the Mutant PDGFRA Receptor

Part Of

Signaling by PDGFR in Disease

PI3K Catalyses the Phosphorylation of PIP2 to PIP3 Downstream of Mutant PDGFR

Autophosphorylation of PDGFR Mutant Dimers

GRB2:SOS1 Complex Binds to Mutant PDGFR Receptor

PI3-Kinase Binds to Mutant PDGFR Receptor

Ligand-Independent Dimerization of PDGFR Mutants