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Constitutive Signaling by Overexpressed ERBB2 - Ontify
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Constitutive Signaling by Overexpressed ERBB2
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9634285).
Statements about
Constitutive Signaling by Overexpressed ERBB2
Exact Match
https://identifiers.org/reactome:R-H ...
Instance Of
Biological Pathway
Has Part(s)
ERBB2 Homodimerization
Trans-Autophosphorylation of ERBB2 Homodimer
SHC1 Binds Phosphorylated ERBB2 Homodimer
ERBB2 Homodimer Phosphorylates SHC1
Recruitment of GRB2:SOS1 to P-SHC1 in Complex with Phosphorylated ERBB2 Homodimer
RAS Guanyl-Nucleotide Exchange Mediated by SOS1 in Complex with GRB2 and ERBB2 Homodimer:p-SHC1
ERBB2 Binds Trastuzumab
ERBB2 Binds TKIs
Part Of
Signaling by ERBB2 in Cancer
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