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Response of EIF2AK1 (HRI) to Heme Deficiency - Ontify
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Response of EIF2AK1 (HRI) to Heme Deficiency
Instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9648895).
Statements about
Response of EIF2AK1 (HRI) to Heme Deficiency
Exact Match
https://identifiers.org/reactome:R-H ...
Instance Of
Biological Pathway
Regulation of eIF2 Alpha Phosphorylation by Heme
Has Part(s)
20 items
Ferriheme Dissociates From P-T-EIF2AK1:2xferriheme Dimer
P-T-EIF2AK1:ferriheme Dimer Autophosphorylates
P-T,T486,T488-EIF2AK1 Phosphorylates EIF2S1 (eIF2-Alpha)
Translation of ATF4
Translation of DDIT3
Translation of PPP1R15A
Translation of ATF5
ATF4 Binds the DDIT3 Promoter
Transcription of DDIT3 (CHOP, GADD153) in Response to Heme Deficiency
ATF4 and a CEBP Protein Bind the ATF5 Promoter
Transcription of ATF5
ATF4, CEBPB, and ATF3 Bind the CHAC1 Promoter
Expression of CHAC1
ATF4 and a CEBP Protein Bind the TRIB3 Promoter
Expression of TRIB3 in Response to Stress
ATF4 Binds the PPP1R15A (GADD34) Promoter
Transcription of PPP1R15A
ATF4 and CEBPB,CEBPG Bind the ASNS Gene
Expression of ASNS (Asparagine Synthetase)
Expression of GRB10
Part Of
Cellular Responses to Stress
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